Erbb2^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Gne
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Genentech
• MGI ID: MGI:1928827
• Synonyms: ErbB2^-
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45302
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of an exon encoding amino acids 256-304 with a neomycin cassette. This mutation disrupts the first extracellular cysteine-rich domain; this region had been demonstated to be the putative ligand interacting site. (J:45302)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:45302 Erickson SL, et al., ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997 Dec;124(24):4999-5011
• All: 3 reference(s)