Dbh^tm2(Th)Rpa
Targeted Allele Detail

Summary

• Symbol: Dbh^tm2(Th)Rpa
• Name: dopamine beta hydroxylase; targeted mutation 2, Richard D Palmiter
• MGI ID: MGI:1928960
• Synonyms: Dbh^Th, DBH-TH^-
• Gene: Dbh Location: Chr2:27055519-27073216 bp, + strand Genetic Position: Chr2, 19.29 cM
• Alliance: Dbh^tm2(Th)Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The entire Th coding region, including 1kb sequence after the polyadenylation site and a neomycin resistance cassette, was inserted between exons 1 and 2 of the Dbh gene. (J:30404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbh Mutation: 17 strains or lines available

References

• Original: J:30404 Zhou QY, et al., Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell. 1995 Dec 29;83(7):1197-209
• All: 23 reference(s)