Musk^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Musk^tm1Gdy
• Name: muscle, skeletal, receptor tyrosine kinase; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:1929066
• Synonyms: MuSK^-
• Gene: Musk Location: Chr4:58285962-58374303 bp, + strand Genetic Position: Chr4, 31.87 cM
• Alliance: Musk^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33132
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of most of the exon encoding subdomains 5-11 of the tyrosine kinase domain and flanking intron sequence with a neomycin cassette. (J:33132)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Musk Mutation: 42 strains or lines available

References

• Original: J:33132 DeChiara TM, et al., The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell. 1996 May 17;85(4):501-12
• All: 18 reference(s)