Erbb2^tm1Haus
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Haus
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Christopher Hauser
• MGI ID: MGI:1929070
• Synonyms: erbB2^-
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Haus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29973
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin cassette replaced 2.0 kb of sequence containing the promoter and first exon. (J:29973)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:29973 Lee KF, et al., Requirement for neuregulin receptor erbB2 in neural and cardiac development [see comments]. Nature. 1995 Nov 23;378(6555):394-8
• All: 10 reference(s)