Erbb2^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Cbm
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:1929071
• Synonyms: erbB2^-
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48515
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Fusion of lacZ sequences to an exon encoding the cytoplasmic juxtamembrane domain. This allele expresses a fusion protein of ErbB2 and beta-galactosidase that lacks the kinase domain of ErbB2. (J:48515)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:48515 Britsch S, et al., The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998 Jun 15;12(12):1825-36
• All: 10 reference(s)