Erbb3^tm2Cbm
Targeted Allele Detail

Summary

• Symbol: Erbb3^tm2Cbm
• Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:1929598
• Synonyms: erbB3^-, Erbb3^KO2
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^tm2Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43515
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin gene was fused to an exon encoding extracellular sequences of the protein, introducing termination codons in all three reading frames. No protein is produced from this allele. (J:43515)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 48 strains or lines available

References

• Original: J:43515 Riethmacher D, et al., Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 1997 Oct 16;389(6652):725-30
• All: 13 reference(s)