Tg(Trp53R172H)8512Jmr
Transgene Detail

Summary

• Symbol: Tg(Trp53R172H)8512Jmr
• Name: transgene insertion 8512, Jeffrey Rosen
• MGI ID: MGI:1929642
• Synonyms: 172R-H, p53-172H, p53(R172H), Wap-p53^R172H
• Transgene: Tg(Trp53R172H)8512Jmr Location: unknown
• Alliance: Tg(Trp53R172H)8512Jmr page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53R172H)8512Jmr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: This transgene contains the rat whey acidic protein promoter and an allele of the mouse Trp53 mini-gene that carries a point mutation in codon 172 (CGC->CAC; Arg172His). (J:46426)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Trp53R172H)8512Jmr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

On an FVB/N background transgenic mice express TRP53 with both dominant-negative and a gain-of function properties.

References

• Original: J:46426 Li B, et al., A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998 Feb 26;16(8):997-1007
• All: 15 reference(s)