Foxn1^nu-StL
Spontaneous Allele Detail

Summary

• Symbol: Foxn1^nu-StL
• Name: forkhead box N1; St Louis
• MGI ID: MGI:1929717
• Synonyms: Whn^StL
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^nu-StL page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• Mutation details: This allele comprises a two base pair insertion (GC) in exon 7 causing a frameshift at amino acid 372, adding 134 unique amino acids. The result is a truncated form of the transcription factor protein that retains the DNA binding domain but lacks the activation domain. This mutation is shown to be allelic to Foxn1 by lack of complementation. Uunlike the original nude allele, the protein of this allele is detected in the nucleus. (J:63313)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:63313 Schorpp M, et al., Genetically separable determinants of hair keratin gene expression. Dev Dyn. 2000 Jul;218(3):537-43
• All: 1 reference(s)