Tcf15^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Tcf15^tm1Eno
• Name: transcription factor 15; targeted mutation 1, Eric N Olson
• MGI ID: MGI:1929775
• Synonyms: paraxis-, paraxis-null
• Gene: Tcf15 Location: Chr2:151985481-151991017 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Tcf15^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37117
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of sequences from the initiating codon through the basic helix-loop-helix (bHLH) region through part of the first intron with a PGK-neomycin cassette. No functional mRNA was detected in homozygous mutants by Northern blot analysis. (J:37117)

Expression

In Mice Carrying this Mutation:	139 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf15 Mutation: 12 strains or lines available

References

• Original: J:37117 Burgess R, et al., Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature. 1996 Dec 12;384(6609):570-3
• All: 9 reference(s)