Hgf^tm1Kita
Targeted Allele Detail

Summary

• Symbol: Hgf^tm1Kita
• Name: hepatocyte growth factor; targeted mutation 1, Naomi Kitamura
• MGI ID: MGI:1929776
• Synonyms: hgf^-, HGF/SF^-
• Gene: Hgf Location: Chr5:16758493-16825150 bp, + strand Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
• Alliance: Hgf^tm1Kita page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23171
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Disruption of the Hgf gene by deletion of part of exon 5, encoding the first kringle domain, and replacement of these sequences with a PGK- neomycin cassette. (J:23171)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgf Mutation: 55 strains or lines available

References

• Original: J:23171 Uehara Y, et al., Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 1995 Feb 23;373(6516):702-5
• All: 3 reference(s)