Agrn^tm1Jrs
Targeted Allele Detail

Summary

• Symbol: Agrn^tm1Jrs
• Name: agrin; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:1929777
• Synonyms: agrin-, agrn^neo, z-agrin^-
• Gene: Agrn Location: Chr4:156249747-156281945 bp, - strand Genetic Position: Chr4, 88.55 cM
• Alliance: Agrn^tm1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33098
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exons 32 and 33, encoding the "z" alternative splice exons, with a neomycin cassette. Note this is a hypomorphic allele for all isoforms of agrin. (J:33098)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agrn Mutation: 102 strains or lines available

References

• Original: J:33098 Gautam M, et al., Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
• All: 18 reference(s)