Bdnf^tm2(Ntf5)Jae
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm2(Ntf5)Jae
• Name: brain derived neurotrophic factor; targeted mutation 2, Rudolf Jaenisch
• MGI ID: MGI:1929985
• Synonyms: Bdnf^nt4-ki
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm2(Ntf5)Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61340
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Ntf5 (reported by authors as NT4) coding sequences were introduced in frame after the first ATG of the Bdnf gene. All remaining coding sequences of the Bdnf gene were deleted. (J:61340)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:61340 Fan G, et al., Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nat Neurosci. 2000 Apr;3(4):350-7
• All: 1 reference(s)