Bdnf^tm1Par
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Par
• Name: brain derived neurotrophic factor; targeted mutation 1, Luis Parada
• MGI ID: MGI:1929986
• Synonyms: BDNF^-, BNDF^tm1-LT
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44286
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into a Sal1 site in the single coding exon of the gene. (J:44286)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:44286 Liebl DJ, et al., Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997 Dec 1;17(23):9113-21
• All: 28 reference(s)