Bdnf^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Gdy
• Name: brain derived neurotrophic factor; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:1930038
• Synonyms: bdnf-
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25565
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• 332bp of the gene was deleted and replaced by a neomycin cassette. (J:25565)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:25565 Conover JC, et al., Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature. 1995 May 18;375(6528):235-8
• All: 16 reference(s)