Bdnf^tm1Lfr
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Lfr
• Name: brain derived neurotrophic factor; targeted mutation 1, Louis F Reichardt
• MGI ID: MGI:1930110
• Synonyms: BDNF-, BDNF^neo
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67231
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of a large region of the coding region and replacement with a neomycin cassette. Deleted sequences include residues required for prohomrone processing and interactions of mature neurotrophins with Trk receptors and with Ngfr. (J:67231)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:67231 Jones KR, et al., Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell. 1994 Mar 25;76(6):989-99
• All: 15 reference(s)