Ntrk2^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Kln
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:1930163
• Synonyms: trkB^shc
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49472
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Point mutation of tyrosine 515 to phenylalanine, and insertion of an frt-flanked neomycin resistance cassette into an adjacent intron. (J:49472)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:49472 Minichiello L, et al., Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron. 1998 Aug;21(2):335-45
• All: 18 reference(s)