Tg(MMTV-Notch4)3Rnc
Transgene Detail

Summary

• Symbol: Tg(MMTV-Notch4)3Rnc
• Name: transgene insertion 3, Robert Callahan
• MGI ID: MGI:1930200
• Synonyms: FF1 int-3, FVB-3, MMTV-int-3, MMTV LTR-INT3, TgN(MMTVInt3)3Rnc
• Transgene: Tg(MMTV-Notch4)3Rnc Location: unknown
• Alliance: Tg(MMTV-Notch4)3Rnc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Notch4)3Rnc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch4 (MGI:107471)

• Mutation details: A 7.5 kb genomic fragment derived from a Czech II mammary tumor was used to generate transgenic mice. The fragment contained MMTV envelope and 3' LTR sequences and a truncated portion of the mouse Notch4 gene. (J:11644)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Notch4)3Rnc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Six founder mice with similar phenotypes noted. One line established.

References

• Original: J:11644 Jhappan C, et al., Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 1992 Mar;6(3):345-55
• All: 3 reference(s)