Tg(WapNotch4)10Rnc
Transgene Detail

Summary

• Symbol: Tg(WapNotch4)10Rnc
• Name: transgene insertion 10, Robert Callahan
• MGI ID: MGI:1930202
• Synonyms: Tg(WapInt3)10Rnc, WAP/Int3, Wap-int3 tg
• Transgene: Tg(WapNotch4)10Rnc Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(WapNotch4)10Rnc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(WapNotch4)10Rnc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Notch4 (406162)

  Notch4

  (MGI:107471)

• Mutation details: The transgene insert consisted of the mouse whey acidic acid promoter and the portion of the Notch4 gene encoding the intracellular domain. Wap promoter activity is restricted to the secretory mammary epithelial population. Four founder mice were identified. One line established from founder 10. Transmission analysis indicates that the transgene inserted into the X chromosome. (J:33193)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(WapNotch4)10Rnc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:33193 Gallahan D, et al., Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res. 1996 Apr 15;56(8):1775-85
• All: 12 reference(s)