Bmp5^se-38DSD
Radiation induced Allele Detail

Summary

• Symbol: Bmp5^se-38DSD
• Name: bone morphogenetic protein 5; short ear, 38DSD
• MGI ID: MGI:1930367
• Gene: Bmp5 Location: Chr9:75682646-75807592 bp, + strand Genetic Position: Chr9, 42.34 cM
• Alliance: Bmp5^se-38DSD page

Mutation origin

• Strain of Origin: (C3H/Rl x 101/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutations: Deletion, Duplication, Inversion
• Mutation details: Evidence of DNA rearrangement at this locus as noted by altered restriction fragment polymorphisms. The Bmp5 open reading frame could not be amplified from strain 38DSD. 38DSD is a 30.7 Mb inversion with breakpoints in intron 6 of Bmp5 and intron 1 of Tmprss4. The Bmp5 breakpoint is between chr9:75,896,515-75,896,518 (4 bp duplicated). The Tmprss4 breakpoint is between chr9:45,190,204-45,190,206 (1 bp deletion). (J:3046, J:39620)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp5 Mutation: 116 strains or lines available

Notes

This mutation was originally generated by treatment of F1 mice with 100 + 500 rads of fractional acute X radiation.

References

• Original: J:3046 Kingsley DM, et al., The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 1992 Oct 30;71(3):399-410
• All: 2 reference(s)