Brca1^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Brca1^tm1Cxd
• Name: breast cancer 1, early onset; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:1930612
• Synonyms: Brca1^11-, Brca1^delta11, Brca1^Ko, brca1^Ko22
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51834
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Deletion of 330 bp of intron 10 and 407 bp of exon 11 and replacement with a neomycin cassette. (J:51834)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:51834 Shen SX, et al., A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998 Dec 17;17(24):3115-24
• All: 22 reference(s)