Brca2^tm1Arge
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Arge
• Name: breast cancer 2, early onset; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:1930615
• Synonyms: Brca2^ex11
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40594
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of a segment of exon 11 with a neomycin cassette. (J:40594)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Arge

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:40594 Ludwig T, et al., Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997 May 15;11(10):1226-41
• All: 2 reference(s)