Brca2^tm1Cam
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Cam
• Name: breast cancer 2, early onset; targeted mutation 1, University of Cambridge
• MGI ID: MGI:1930616
• Synonyms: Brca2^Tr
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Cam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46812
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a beta-geo selection cassette into exon 11 and deletion of nucleotides 4668-4989. This allele expresses a truncated protein at amino acid 1492, similar to truncating mutations found in humans. (J:46812)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Cam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:46812 Friedman LS, et al., Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 1998 Apr 1;58(7):1338-43
• All: 6 reference(s)