Brca2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Mak
• Name: breast cancer 2, early onset; targeted mutation 1, Tak W Mak
• MGI ID: MGI:1930617
• Synonyms: Brca2^10-11
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40595
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the 3' half of exon 10, intron 10 and the 5'end of exon 11 with a neomycin cassette. (J:40595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:40595 Suzuki A, et al., Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52
• All: 3 reference(s)