H19^tm1Tilg
Targeted Allele Detail

Summary

• Symbol: H19^tm1Tilg
• Name: H19, imprinted maternally expressed transcript; targeted mutation 1, Shirley M Tilghman
• MGI ID: MGI:1930620
• Synonyms: deltaH19, H19^-, H19^delta13
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^tm1Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25091
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding region (3kb) and 10kb of 5' flanking sequence. (J:25091)

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying H19^tm1Tilg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 12 strains or lines available

References

• Original: J:25091 Leighton PA, et al., Disruption of imprinting caused by deletion of the H19 gene region in mice [see comments]. Nature. 1995 May 4;375(6526):34-9
• All: 24 reference(s)