En1^tm4(en)Alj
Targeted Allele Detail

Summary

• Symbol: En1^tm4(en)Alj
• Name: engrailed 1; targeted mutation 4, Alexandra L Joyner
• MGI ID: MGI:1930647
• Synonyms: EN1^dkin
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm4(en)Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50311
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Insertion of the Drosophila engrailed (en) gene into the En1 locus. A loxP flanked neomycin cassette is retained. Note that retention of neo was reported to reduce en expression in this allele. (J:50311)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 34 strains or lines available

References

• Original: J:50311 Hanks MC, et al., Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development. Development. 1998 Nov;125(22):4521-30
• All: 1 reference(s)