Rr28^tm1Tilg
Targeted Allele Detail

Summary

• Symbol: Rr28^tm1Tilg
• Name: regulatory region 28; targeted mutation 1, Shirley M Tilghman
• MGI ID: MGI:1930789
• Synonyms: Enh(delta), H19^tm2Tilg, Rr27^tm1Tilg
• Gene: Rr28 Location: Chr7:142122776-142124725 bp Genetic Position: Chr7, Syntenic
• Alliance: Rr28^tm1Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28716
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of a 6.2kb region downstream of H19 which contains the H19 and Igf2 endoderm-specific enhancers and a DNaseI hypersensitive site. (J:28716)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr28 Mutation: 0 strains or lines available

References

• Original: J:28716 Leighton PA, et al., An enhancer deletion affects both H19 and Igf2 expression. Genes Dev. 1995 Sep 1;9(17):2079-89
• All: 5 reference(s)