En2^tm3Alj
Targeted Allele Detail

Summary

• Symbol: En2^tm3Alj
• Name: engrailed 2; targeted mutation 3, Alexandra L Joyner
• MGI ID: MGI:1930811
• Synonyms: En2^pbdneo
• Gene: En2 Location: Chr5:28370692-28377164 bp, + strand Genetic Position: Chr5, 13.94 cM
• Alliance: En2^tm3Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60433
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of two adjacent Pax-binding sites (66 bp) in the regulatory region with a lox-P flanked neomycin cassette. This allele is hypomorphic for the expression of the gene. (J:60433)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En2 Mutation: 104 strains or lines available

References

• Original: J:60433 Li Song D, et al., Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression. Mech Dev. 2000 Feb;90(2):155-65
• All: 1 reference(s)