Rr27^tm1.1Msb
Targeted Allele Detail

Summary

• Symbol: Rr27^tm1.1Msb
• Name: regulatory region 27; targeted mutation 1.1, Marisa S Bartolomei
• MGI ID: MGI:1930816
• Synonyms: H19^deltaDMD, H19^tm1.1Msb
• Gene: Rr27 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm1.1Msb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52162
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance cassette replaced a region of the gene from approximately -2 to -4kb relative to the transcription start site (the DMD domain). Cre-mediated recombination removed the neomycin cassette in this derivative of Rr27^tm1Msb. (J:52162)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:52162 Thorvaldsen JL, et al., Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 1998 Dec 1;12(23):3693-702
• All: 4 reference(s)