Psen1^tm1Pcw
Targeted Allele Detail

Summary

• Symbol: Psen1^tm1Pcw
• Name: presenilin 1; targeted mutation 1, Philip C Wong
• MGI ID: MGI:1930934
• Synonyms: PS1^-
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40308
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.9kb of sequence containing the second coding exon. Immunoblot analysis using antibodies specific for epitopes contained within each of the endoproteolytic products of the gene did not detect protein in SDS extracts of homozygous mutant E18.5 embryos. (J:40308)

Disease models

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 48 strains or lines available

References

• Original: J:40308 Wong PC, et al., Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 1997 May 15;387(6630):288-92
• All: 40 reference(s)