Ifnar1^tm1Agt
Targeted Allele Detail

Summary

• Symbol: Ifnar1^tm1Agt
• Name: interferon (alpha and beta) receptor 1; targeted mutation 1, Michel Aguet
• MGI ID: MGI:1930950
• Synonyms: A^-, A 129, A129, IFN-alpha/betaR-, IFN-alphabetaR-, IFN-alpha/betaR⁰, IFN-alpha/betaR/A129, IFN-alphabeta-R KO, IFN Alpha Ro/o, IFNAR^-, IFNAR(0), Ifnar1-, IFN-IR^-, IFN-IR KO, IFNR^-, IFNRA1,-., IFNRI -, IFNRI KO, IFN type I receptor
• Gene: Ifnar1 Location: Chr16:91282126-91304329 bp, + strand Genetic Position: Chr16, 52.98 cM
• Alliance: Ifnar1^tm1Agt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36115
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into exon 3 at a position corresponding to amino acid 88. (J:36115, J:96036)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	30 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 11 strains available Cell Lines: 0 lines available
• Carrying any Ifnar1 Mutation: 60 strains or lines available

References

• Original: J:36115 Muller U, et al., Functional role of type I and type II interferons in antiviral defense. Science. 1994 Jun 24;264(5167):1918-21
• All: 1136 reference(s)