Dnmt1^tm2Enl
Targeted Allele Detail

Summary

• Symbol: Dnmt1^tm2Enl
• Name: DNA methyltransferase 1; targeted mutation 2, En Li
• MGI ID: MGI:1930971
• Synonyms: Dnmt1^-, Dnmt1^c, Dnmt^c
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^tm2Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36234
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of two exons encoding the catalytic domain and replacement with either a neomycin or hygromycin cassette. (J:36234)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dnmt1^tm2Enl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 112 strains or lines available

References

• Original: J:36234 Lei H, et al., De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996 Oct;122(10):3195-205
• All: 17 reference(s)