Uchl3^tm1Tilg
Targeted Allele Detail

Summary

• Symbol: Uchl3^tm1Tilg
• Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); targeted mutation 1, Shirley M Tilghman
• MGI ID: MGI:1930988
• Synonyms: Uch-L3^delta3-7
• Gene: Uchl3 Location: Chr14:101891403-101933561 bp, + strand Genetic Position: Chr14, 50.9 cM
• Alliance: Uchl3^tm1Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61093
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exons 3 - 7, which encode ~90% of the protein, with a neomycin cassette. (J:61093)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uchl3 Mutation: 28 strains or lines available

References

• Original: J:61093 Kurihara LJ, et al., Expression and functional analysis of Uch-L3 during mouse development. Mol Cell Biol. 2000 Apr;20(7):2498-504
• All: 11 reference(s)