Trp53^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Brn
• Name: transformation related protein 53; targeted mutation 1, Anton Berns
• MGI ID: MGI:1931011
• Synonyms: p53^Co, p53^f, p53^F, p53^F2-10, p53^F2-10F, p53^fl, p53^Fl, p53Fl, p53^flox, p53^L, p53^lox, p53^LoxP, Tp53^flox, Tp53^flx, Trp53^f, Trp53^F2-10, Trp53^F2-F10, Trp53^Fl, Trp53^lox, Trp53^loxP, Trp53-loxP flanked
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Brn page

High-grade prostate intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0 Trp53^tm1Brn/Trp53^tm1Brn and prostate hyperplasia and intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(Pbsn-cre)4Prb/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61961
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Insertion of loxP sites flanking exons 2 through 10. No effect on the normal function of the gene. (J:61961)

Disease models

Expression

In Mice Carrying this Mutation:	141 assay results 13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 18 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
• All: 1208 reference(s)