Rb1^tm2Brn
Targeted Allele Detail

Summary

• Symbol: Rb1^tm2Brn
• Name: RB transcriptional corepressor 1; targeted mutation 2, Anton Berns
• MGI ID: MGI:1931018
• Synonyms: flox19-RB1, pRb^L2, pRb^lox, Rb^f, Rb^F19, Rb^lox, Rb^LoxP
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm2Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61961
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis. (J:61961)

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

Notes

Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.

Phenotypic Similarity to Human Syndrome: Glucagonoma J:216559 in double homozygous Rb1 and Trp53 conditional mutants.

References

• Original: J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
• All: 218 reference(s)