Vegfa^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm1Pec
• Name: vascular endothelial growth factor A; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:1931047
• Synonyms: VEGF¹²⁰
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56003
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exons 6 and 7 with a lox-P flanked neomycin cassette. The neomycin cassette was removed prior to blastocyst injection by Cre-mediated recombination in ES cells, resulting in the final allele. A highly soluble isoform of the encoded protein is expressed from this allele. (J:56003)

Disease models

Expression

In Mice Carrying this Mutation:	68 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 38 strains or lines available

References

• Original: J:56003 Carmeliet P, et al., Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments]. Nat Med. 1999 May;5(5):495-502
• All: 32 reference(s)