Vegfa^tm2Gne
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm2Gne
• Name: vascular endothelial growth factor A; targeted mutation 2, Genentech
• MGI ID: MGI:1931048
• Synonyms: Vegf-A/loxP, VEGF^+f, VEGF^Flox, VEGF^lox, VEGFloxP, VEGFloxP(-)
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm2Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52793
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of a loxP-flanked neomycin cassette and a loxP site flanking exon 3. This mutation had no effect on the secretion of the protein. (J:52793)

Expression

In Mice Carrying this Mutation:	1 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Vegfa^tm2Gne

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 38 strains or lines available

References

• Original: J:52793 Gerber HP, et al., VEGF is required for growth and survival in neonatal mice. Development. 1999 Mar;126(6):1149-59
• All: 149 reference(s)