Egr2^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Egr2^tm1Grid
• Name: early growth response 2; targeted mutation 1, Tom Gridley
• MGI ID: MGI:1931057
• Synonyms: Krox20^-, Krox20^deltazf
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15577
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of sequences encoding the N-terminal zinc-finger domain with a neomycin selection cassette. (J:15577)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 33 strains or lines available

References

• Original: J:15577 Swiatek PJ, et al., Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 1993 Nov;7(11):2071-84
• All: 8 reference(s)