Fgf3^tm2Mrc
Targeted Allele Detail

Summary

• Symbol: Fgf3^tm2Mrc
• Name: fibroblast growth factor 3; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:1931060
• Synonyms: int-2-lacZ, int-2^lacZ
• Gene: Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fgf3^tm2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4501
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a lacZ-neomycin resistance cassette into exon 1b placed lacZ coding sequences several codons downstream from the signal peptide-coding sequence, and in-frame with Fgf3 coding sequences. This allele expresses beta-galactosidase in a pattern that reflects the expression of wild-type Fgf3 mRNA. RT-PCR analyses of homozygous mutant embryos detected no transcripts. (J:67740)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf3 Mutation: 16 strains or lines available

References

• Original: J:4501 Mansour SL, et al., Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 1993 Jan;117(1):13-28
• All: 2 reference(s)