Fgf4^tm1.2Mrt
Targeted Allele Detail

Summary

• Symbol: Fgf4^tm1.2Mrt
• Name: fibroblast growth factor 4; targeted mutation 1.2, Gail R Martin
• MGI ID: MGI:1931062
• Synonyms: Fgf4^clc, Fgf4^flox
• Gene: Fgf4 Location: Chr7:144415123-144418982 bp, + strand Genetic Position: Chr7, 88.88 cM
• Alliance: Fgf4^tm1.2Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61886
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is a derivative of Fgf4^tm1.1Mrt where the frt-flanked neomycin selection cassette was removed by Flp-mediated recombination by crossing mice carrying the Fgf4^tm1.1Mrt allele with mice expressing Flp recombinase under the control of a beta-actin promoter (J:74965). (J:61886)

Expression

In Mice Carrying this Mutation:

31 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf4 Mutation: 30 strains or lines available

References

• Original: J:61886 Sun X, et al., Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet. 2000 May;25(1):83-6
• All: 16 reference(s)