Rarg^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Rarg^tm1Ipc
• Name: retinoic acid receptor, gamma; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:1931079
• Synonyms: Agamma, RARgamma^-
• Gene: Rarg Location: Chr15:102143373-102165891 bp, - strand Genetic Position: Chr15, 57.4 cM, cytoband E-F3
• Alliance: Rarg^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:12691
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon 8 at the position corresponding to amino acid 75 of the gamma1 isoform disrupted Rarg in the B region common to all isoforms. This disruption is predicted to prevent the synthesis of all RARG isoforms. RNase protection analysis of E13.5 embryos indicated that the mRNAs encoding the both the gamma1 and the gamma2 isoforms were mutated in this allele, and did not detect the wild-type transcript for either isoform. (J:12691)

Expression

In Mice Carrying this Mutation:	122 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rarg Mutation: 151 strains or lines available

Notes

Homozygous mutants show growth deficiency and increased post-natal early lethality. Mutants also show a variety of homeotic transformations of the axial skeleton.

References

• Original: J:12691 Lohnes D, et al., Function of retinoic acid receptor gamma in the mouse. Cell. 1993 May 21;73(4):643-58
• All: 33 reference(s)