Lpar1^tm1Jch
Targeted Allele Detail

Summary

• Symbol: Lpar1^tm1Jch
• Name: lysophosphatidic acid receptor 1; targeted mutation 1, Jerod Chun
• MGI ID: MGI:1931154
• Synonyms: lpa1-, LPA1-null, Lpar1^-
• Gene: Lpar1 Location: Chr4:58435255-58553898 bp, - strand Genetic Position: Chr4, 32.2 cM
• Alliance: Lpar1^tm1Jch page

Gross abnormalities in Lpar1^tm1Jch/Lpar1^tm1Jch mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65882
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites that flanked exon 3 were inserted by homologous recombination. The loxP-flanked sequences were then deleted by transient cre mediated recombination in ES cells prior to the production of chimeric animals. No mRNA was detected in adult brain derived from homozygous mice. (J:65882)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpar1 Mutation: 71 strains or lines available

References

• Original: J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
• All: 40 reference(s)