Brca1^tm2Cxd
Targeted Allele Detail

Summary

• Symbol: Brca1^tm2Cxd
• Name: breast cancer 1, early onset; targeted mutation 2, Chu-Xia Deng
• MGI ID: MGI:1931238
• Synonyms: Brca1^Co, Brca1^F11, Brca1^flox, Brca1^lox
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm2Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54533
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of lox-P sites flanking exon 11. A lox-P flanked neomycin cassette in intron 10 was removed by transient Cre expression in ES cells in this allele. Insertions have no effect on normal gene function. (J:54533)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm2Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:54533 Xu X, et al., Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments]. Nat Genet. 1999 May;22(1):37-43
• All: 82 reference(s)