Nr3c1^tm2.1Gsc
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm2.1Gsc
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 2.1, Gunther Schutz
• MGI ID: MGI:1931328
• Synonyms: GRN^-, GR^null
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm2.1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54931
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele is a derivative of Nr3c1^tm2Gsc in which loxP sites were inserted to flank exon 3. Transient Cre expression in ES cells was used to deletion the third exon. (J:54931)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 35 strains or lines available

References

• Original: J:54931 Finotto S, et al., Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development. 1999 Jul;126(13):2935-44
• All: 16 reference(s)