Nr5a1^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Nr5a1^tm1Jmi
• Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:1931426
• Synonyms: SF1 -
• Gene: Nr5a1 Location: Chr2:38582668-38604554 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr5a1^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35577
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of ~100 bp of genomic sequence with a neomycin cassette. This region corresponded to the coding sequences for one of the zinc finger domains. (J:35577)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr5a1 Mutation: 30 strains or lines available

References

• Original: J:35577 Sadovsky Y, et al., Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10939-43
• All: 2 reference(s)