About   Help   FAQ
H2-K1b-tm1Bpe
Targeted Allele Detail
Summary
Symbol: H2-K1b-tm1Bpe
Name: histocompatibility 2, K1, K region; targeted mutation 1, Beatrice Perarnau
MGI ID: MGI:1931444
Synonyms: H2-K1tm1Bpe, H2-Kb-, H-2Ko, K-, Kb-
Gene: H2-K1  Location: Chr17:34214986-34219316 bp, - strand  Genetic Position: Chr17, 17.98 cM
Alliance: H2-K1b-tm1Bpe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54709
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe central part of the H2-K gene, including the second and third exons was replaced by a HPRT minigene. (J:41077, J:54709)
Inheritance:    Recessive
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
           
behavior/neurological
enhanced coordination
hematopoietic system
N
hematopoietic system phenotype
N N
increased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
absent CD8-positive, alpha-beta T cells
abnormal NK cell physiology
abnormal cytotoxic T cell physiology
immune system
increased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
absent CD8-positive, alpha-beta T cells
abnormal NK cell physiology
abnormal cytotoxic T cell physiology
increased susceptibility to systemic lupus erythematosus
decreased susceptibility to Riboviria infection induced morbidity/mortality
mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality
premature death
nervous system
nervous system phenotype
N
abnormal glutamate-mediated receptor currents
increased synaptic depression
enhanced paired-pulse facilitation
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
Tumor Data
List all tumor models in MMHCdb carrying H2-K1b-tm1Bpe
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any H2-K1 Mutation:  60 strains or lines available
References
Original:  J:54709 Perarnau B, et al., Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses. Eur J Immunol. 1999 Apr;29(4):1243-52
All:  152 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

Building initial tooltip...