Vtn^tm1Dgi
Targeted Allele Detail

Summary

• Symbol: Vtn^tm1Dgi
• Name: vitronectin; targeted mutation 1, David Ginsburg
• MGI ID: MGI:1931522
• Synonyms: VN-
• Gene: Vtn Location: Chr11:78389946-78393151 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Vtn^tm1Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30296
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette replaced all eight exons. Western blot analysis did not detect protein in plasma of homozygous mutant mice, and cell adhesion experiments with sera derived from homozygous mice demonstrated that serum spreading activity was absent. (J:30296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vtn Mutation: 22 strains or lines available

References

• Original: J:30296 Zheng X, et al., Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12426-30
• All: 28 reference(s)