Proz^tm1Gjb
Targeted Allele Detail

Summary

• Symbol: Proz^tm1Gjb
• Name: protein Z, vitamin K-dependent plasma glycoprotein; targeted mutation 1, George J Broze, Jr
• MGI ID: MGI:1931524
• Synonyms: PZ-
• Gene: Proz Location: Chr8:13110914-13126026 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A2
• Alliance: Proz^tm1Gjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62716
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of a 139 bp fragment of exon 2, encoding a portion of the signal sequence and the N-terminus, with a neomycin cassette. The protein was not detectable in the plasma of homozyogous mutant mice by Western blotting. (J:62716)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Proz Mutation: 30 strains or lines available

References

• Original: J:62716 Yin ZF, et al., Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8
• All: 6 reference(s)