Sftpd^tm1Jhf
Targeted Allele Detail

Summary

• Symbol: Sftpd^tm1Jhf
• Name: surfactant associated protein D; targeted mutation 1, James H Fisher
• MGI ID: MGI:1931530
• Synonyms: Sftpd^-, SP-D(-)
• Gene: Sftpd Location: Chr14:40894171-40907106 bp, - strand Genetic Position: Chr14, 22.36 cM
• Alliance: Sftpd^tm1Jhf page

Progressive enlargement of alveolar macrophages from Sftpd^tm1Jhf/Sftpd^tm1Jhf mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50436
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neomycin cassette. (J:50436)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sftpd Mutation: 17 strains or lines available

References

• Original: J:50436 Korfhagen TR, et al., Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem. 1998 Oct 23;273(43):28438-43
• All: 30 reference(s)