Sftpd^tm1Haw
Targeted Allele Detail

Summary

• Symbol: Sftpd^tm1Haw
• Name: surfactant associated protein D; targeted mutation 1, Samuel Hawgood
• MGI ID: MGI:1931531
• Synonyms: Sftpd^-, Spd-, SP-D-
• Gene: Sftpd Location: Chr14:40894171-40907106 bp, - strand Genetic Position: Chr14, 22.36 cM
• Alliance: Sftpd^tm1Haw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50147
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 2 with a neomycin cassette. (J:50147)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sftpd Mutation: 17 strains or lines available

References

• Original: J:50147 Botas C, et al., Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11869-74
• All: 37 reference(s)