Serpinb2^tm1Dgi
Targeted Allele Detail

Summary

• Symbol: Serpinb2^tm1Dgi
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 2; targeted mutation 1, David Ginsburg
• MGI ID: MGI:1931532
• Synonyms: PAI-2-
• Gene: Serpinb2 Location: Chr1:107439153-107453330 bp, + strand Genetic Position: Chr1, 50.34 cM
• Alliance: Serpinb2^tm1Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52283
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3-8. Western analysis of cultured monocytes did not detect immunoreactive protein in homozygous mutant mice.

Tumor Data

List all tumor models in MMHCdb carrying Serpinb2^tm1Dgi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpinb2 Mutation: 32 strains or lines available

References

• Original: J:52283 Dougherty KM, et al., The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):686-91
• All: 17 reference(s)